Corrigendum-Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)

The Corrigendum-Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO) is a solicitation aimed at obtaining innovative research‑development, healthcare service, and experimental development solutions that advance the ARPA‑H Health Science Futures mission. The HSF mission seeks to eliminate scientific and technological barriers to future healthcare by fostering disease‑agnostic research programs with the potential for translational real‑world impact. The ISO solicits solution summaries, followed by full proposals, that align with this ambitious directive.

Proposals submitted under this ISO involve cutting‑edge R&D services and experimental development initiatives that are intended to break new ground in the physical, engineering, and life sciences. The procurement focuses on projects that can be translated into tangible healthcare improvements and are expected to generate breakthroughs that can be applied across a broad range of medical challenges. Proposers are encouraged to provide detailed summaries of their scientific approach and a clear plan for translating laboratory insights into real‑world solutions.

All submissions must satisfy updated administrative and technical requirements, including compliance with conflict‑of‑interest and research security disclosures, adherence to revised intellectual property assertion guidelines, and updated human and animal subjects research and biosecurity protocols. The cost proposals must incorporate the newly defined burdened labor rates, increase the material documentation threshold to $10,000, and acknowledge that profit/fee is presumed inapplicable unless explicitly stated.

Contract Opportunity Type: Solicitation (o)

Product Service Code: AN13-HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT
NAICS Code:
541715-Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change.

• Solution summary submissions must be submitted to: https://solutions.arpa-h.gov
• Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/
• Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/

Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents:   

1) Administrative & National Policy Requirements Document

• Updated the instructions and references within the “Organizational Conflicts of Interest (OCI) Affirmations and Disclosure” section.
• Updated questions, instructions, and content within the “Research Security Disclosure” section.
• Updated the instructions and intellectual property data assertions charts within the “IP” section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the “Non-Commercial” and “Commercial” tables were removed and replaced with the “Background IP and Data Assertions” table.
• Eliminated the “Software Component Standards” section.
• Updated the Human Subjects Research (HSR) table within the “HSR” section.
• Updated the Animal Subjects Research (ASR) table within the “ASR” section.
• Updated the questions and instructions within the “Biosecurity” section.

2) Cost Proposal Document (Word document)

• Updated the instructions within the “Level of Effort and Labor Costs” section. Added definitions for “burdened labor rate” and “fully burdened labor rate” to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks.
• Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000.

3) Cost Proposal Workbooks (Excel spreadsheets)

• Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook.
• Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000).

Notice ID: ARPA-H-SOL-24-104

Additional buyer information

Department/Ind. Agency: HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier: NATIONAL INSTITUTES OF HEALTH
Major Command: ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)